Sertraline Hydrochloride

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Sertraline (Generic)
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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on October 13, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.


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How to buy Zoloft (Sertraline) online?

To place an order for Zoloft (Sertraline) call 1-800-828-4489 and speak to customer support or online through 90daymeds.com. The chat feature can also be used for support. For more information please visit the “How to Order” page on 90daymeds.com.

Is a prescription required?

Yes, Zoloft (Sertraline) is a prescription medication that can only be sold with a prescription. A valid prescription from your doctor is required. To process your order, you will need to submit a prescription. The prescription can be uploaded , emailed, or faxed (1-800-416-8019). Alternatively, we can reach out to your doctor to acquire a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply is the maximum amount that can be ordered at one time. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider. Refills are kept on file for future orders.

Is it safe to order Zoloft (Sertraline) from 90-Day Meds?

Absolutely. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee.

Zoloft Cost

Average US Retail Price 90-Day Meds Price
Zoloft 100 mg
(90 tablets)
(84 tablets)
Sertraline 100 mg
(90 tablets)
(84 tablets)

How much does Zoloft (Sertraline) cost?

At 90DayMeds.com, we make sure to keep drug prices low. You can view the Zoloft (Sertraline) cost savings below:

We provide brand and generic Zoloft (Sertraline) 100 mg tablets here at 90-Day Meds. A quantity of 84 tablets of brand Zoloft (Sertraline) costs $90, which comes out to $1.07 per unit. A quantity of 84 tablets of generic Zoloft (Sertraline) costs $42, which comes out to $0.50 per unit.

Below shows the price comparison of brand and generic Zoloft (Sertraline) 100 mg at a quantity 84 tablets between the average U.S. retail price and 90-Day Meds price.

What is the lowest price of Zoloft (Sertraline) per unit?

Lowest Price Per Unit: $0.50/unit for generic Zoloft (Sertraline) 100 mg tablets

Is this price for Zoloft (Sertraline) without insurance?

The prices mentioned above are without insurance. Unfortunately, we are not able to accept insurance. However, we will give you an official, itemized receipt that you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Zoloft (Sertraline) cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries. 

Zoloft Coupon

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Is there a lower cost generic Zoloft (Sertraline) available?

Zoloft (Sertraline) is available as a generic alternative.

How much cheaper is generic Zoloft (Sertraline)?

Generic Zoloft (Sertraline) is $48 cheaper than brand Zoloft at a quantity of 84 tablets.

What is the difference between brand and generic Zoloft (Sertraline)?

There is no difference between generic and brand Zoloft (Sertraline). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. Placing a refill order online is made simple by accessing the reorder section in your account. You can sign into your online account and view your previous orders and see which prescriptions we have on file. You can also call us and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Zoloft (Sertraline)?

Zoloft (Sertraline) is a prescription medication that is classified as a selective serotonin reuptake inhibitor (SSRI).


What is Zoloft used for?

It is used for the treatment of major depressive disorder (MDD), Obsessive-compulsive disorder (OCD), Panic disorder (PD), Post-traumatic stress disorder (PTSD), Social anxiety disorder (SAD), and Premenstrual dysphoric disorder (PMDD).

How does it work?

Zoloft inhibits the neuronal reuptake of serotonin which enhances serotonergic activity in the central nervous system.


How do I take Zoloft (Sertraline)?

Zoloft (Sertraline) should be taken as directed by your physician. It is important to note, your dose may need to be adjusted many times before it works best for you. The effects of this medication may take weeks to months. This medication may be taken with or without food.

What dosages are available?

Zoloft (Sertraline) is available as brand and generic 25 mg, 50 mg, and 100 mg tablets. It is also available as a 20 mg/mL oral solution.

What is the recommended dosage?

The recommended dose varies based on patient-specific factors and for the different indications for use. Refer to your doctor for dosing recommendations.

What is the maximum dosage?

The maximum recommended dosage is 200 to 400 mg/day.

What if I miss a dose?

If you forget to take Zoloft (Sertraline), take it as soon as you remember. If it is relatively close to when your next dose is due, wait until then and take a normal dose. Do not double your dose to make up for the missed dose.


What should you know before you take Zoloft (Sertraline)?

Possible risk of serotonin syndrome when taking Zoloft as monotherapy and increased risk if taking concomitantly with other serotonergic agents. If you notice signs of serotonin syndrome, discontinue the medication and let your doctor know.

Increased risk of bleeding if taken concomitantly with: aspirin, nonsteroidal antiinflammatory drugs (NSAIDs), antiplatelet drugs, warfarin, and other anticoagulants.

Patients need to be screened for bipolar disorder prior to initiation because this medication can cause activation of mania/hypomania

Use in caution with patients who have seizure disorders

Avoid use in patients with untreated narrow angle glaucoma

Side Effects

What are the side effects of Zoloft (Sertraline)?

Some common (≥5%) side effects include:

  • Nausea
  • Diarrhea/loose stool
  • Tremor
  • Dyspepsia
  • Decreased appetite
  • Hyperhidrosis
  • Ejaculation failure
  • Decreased libido

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Monitor for adverse effects and potentially reduce dose when Zoloft is used with protein-bound drugs

Reduce the dose of drugs metabolized by CYP2D6

Avoid drinking alcohol with this medication as it may cause increased drowsiness


How should this medication be stored?

Zoloft (Sertraline) should be stored in the original packaging at room temperature (68°F to 77°F)

Pharmacist Tips

  • Some symptoms of serotonin syndrome include: agitation, hallucinations, change in mental status, muscle twitching and/or rigidity, racing heartbeat, sweating or fever. If these apply to you, immediately discontinue this medication and seek medical attention.
  • This medication may increase suicidal thoughts and actions in young adults. Report symptoms to your doctor and keep follow-up visits so your doctor is able to monitor for these symptoms.
  • This medication may cause drowsiness. Take the first dose at night after you are done driving to see how it affects you before resuming normal daily activities.
  • Take at the same time every day to avoid missing doses. This medication works best if you take consistently and minimize missed doses.


Are Zoloft and Xanax the same thing?

No, these medications are in two different drug classes and are not typically compared head-to-head in clinical trials. Typically, Zoloft is for long-term management and Xanax is sometimes used for short-term management of depression.

How does Zoloft make you feel?

It can make patients less anxious, increase appetite, improve sleep quality and energy levels, and improve quality of daily life.

Can you drink alcohol on Zoloft?

It is not recommended because alcohol can enhance the drowsiness effects of Zoloft.

Can you gain weight while taking Zoloft?

Zoloft can improve mood and increase appetite so therefore weight gain has been reported from this medication.

What time of day should you take Zoloft?

It depends on if this medication makes you drowsy. If this medication makes you drowsy then take at bedtime but if it does not, you can take it at any time of the day.


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.