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Levothyroxine Sodium
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How to buy Synthroid (Levothyroxine) online?

Synthroid (Levothyroxine) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on 

Is a prescription required?

Yes, Synthroid (Levothyroxine) is a prescription medication and can only be sold with a prescription.  A valid prescription from your doctor is required.  To process your order, you will need to submit a prescription. The prescription can be uploaded, emailed ([email protected]), or faxed (1-800-416-8019). Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider. Refills are kept on file for future orders.

Is it safe to order Synthroid (Levothyroxine) from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee.


Average US Retail Price 90-Day Meds Price
Synthroid 50 mcg
(90 tablets)
$173.09 $35.00

How much does Synthroid (Levothyroxine) cost?

At, we make sure to keep drug prices low. You can view the Synthroid cost savings above with the price comparison of Synthroid 50mcg  between the average U.S. retail price and 90-Day Meds price.

What is the lowest price of Synthroid (Levothyroxine) per unit?

Lowest Price Per Unit: $0.39/unit for Synthroid (Levothyroxine) 50 mcg tablets 

Is this price for Synthroid (Levothyroxine) without insurance?

The prices mentioned above are without insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Synthroid (Levothyroxine) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price may differ since pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 


Sorry, we do not have a Synthroid (Levothyroxine) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.


Is there a lower cost generic Synthroid (Levothyroxine) available?

Synthroid (Levothyroxine) is not available as a generic alternative.

How much cheaper is generic Synthroid (Levothyroxine)?

There is currently no generic alternative to Synthroid (Levothyroxine). 

What is the difference between brand and generic Synthroid (Levothyroxine)?

Once available on the market, there will be no difference between generic and brand Synthroid (Levothyroxine). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation. 


Is shipping available to the United States?

Yes. Your brand Synthroid (Levothyroxine)  will be shipped from Canada to the United States in 7 to 10  business days. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account. You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go. 

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Synthroid (Levothyroxine)?

Synthroid (Levothyroxine) is a prescription medication that is classified as a synthetic T4.


What is it used for?

used to treat hypothyroidism and TSH suppression. 

How does it work?

Triiodothyronine (T3) and levothyroxine (T4) diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA which affects DNA transcription and protein synthesis. 


How do I take Synthroid (Levothyroxine)?

Take Synthroid (Levothyroxine) as directed by your physician, on an empty stomach 30 minutes to 1 hour prior to breakfast.

What dosages are available?

Synthroid (Levothyroxine) is available as brand 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg, and 300 mcg tablets.

What is the recommended dosage?

Generally it is dosed generally 1.6 mcg/kg once daily but take as directed by your doctor. 

What is the maximum dosage?

The maximum recommended dosage is 300 mcg/day.

What if I miss a dose?

If you miss a dose take it as soon as you remember, as long as it is not near a meal. If it is relatively close to your next dose, wait till then and take a regular dose, do not take an extra dose to make up for the missed dose. 


What should you know before you take Synthroid (Levothyroxine)?

Synthroid (Levothyroxine) can put you at increased risk of heart related adverse reactions. If you have a pre-existing heart condition make sure your doctor is aware before you start taking Synthroid (Levothyroxine). If you experience heart related symptoms (increased heart rate, blood pressure, abnormal heart rhythm, chest pain, shortness of breath) while taking Synthroid (Levothyroxine) you should seek medical attention. 

Synthroid (Levothyroxine) has what is referred to as a narrow therapeutic index. This means that there is a fine line between undertreating and overtreating your condition. This also means that it is imperative to follow all instructions given by your physician as failing to do so can either continue to precipitate your ongoing condition or produce potentially dangerous adverse events. 

Patients with existing diabetes can expect Synthroid (Levothyroxine) to worsen their ability to control sugar levels. Most patients will require more insulin to regulate their blood sugar after starting Synthroid (Levothyroxine). It is very important for these patients to regularly check their blood sugar after starting Synthroid (Levothyroxine) and after each potential subsequent change in their dose of Synthroid (Levothyroxine) to reduce risks of hyperglycemia (or hypoglycemia if there is a dose reduction). 

If you are on a supratherapeutic (too high) dose for an extended period of time it could put you at risk for decreased bone mineral density. Particularly in post menopausal women, you should ensure you are having your thyroid levels checked routinely to ensure that your dose requirements have not changed. 

Side Effects

What are the side effects of Synthroid (Levothyroxine)?

Some common side effects include:

  • arrhythmias 
  • Myocardial infarction 
  • Dyspnea
  • Muscle spasm
  • Headache
  • Nervousness
  • Irritability
  • Insomnia 
  • Tremors
  • Muscle weakness
  • Increased appetite
  • Weight loss
  • Diarrhea
  • Heat intolerance 
  • Menstrual Irregularities
  • Skin rash 

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Synthroid (Levothyroxine) has extensive drug interactions as thyroid absorption, synthesis, secretion, catabolism, protein binding, and target tissue response can all be affected by other medications. Ensure you have a complete list of medications initially and each time your thyroid levels are evaluated to provide your physician with information about why your thyroid levels may or may not have changed. 

It is safe to assume that Synthroid (Levothyroxine) should be separated by all other medications by at least 30 minutes as many can alter the absorption of Synthroid (Levothyroxine). 


How should this medication be stored?

Synthroid (Levothyroxine) should be stored at room temperature (77°F) 

Pharmacist Tips

  • It may take several weeks before you notice significant changes in your symptoms. 
  • Synthroid (Levothyroxine) is intended to repleat the thyroid hormone normally produced by your body, most people are on Synthroid (Levothyroxine) as a lifelong therapy. 
  • Ensure that any changes made to your other medications are relayed to your physician as starting or stopping medications can affect your overall thyroid levels. 


What foods should be avoided when taking Synthroid (Levothyroxine)?

Certain foods can affect the absorption of Synthroid (Levothyroxine). Soybean flour, cottonseed meal, walnuts, and dietary fiber may bind to and decrease the absorption of Synthroid (Levothyroxine). Additionally grapefruit juice may delay time of absorption and affect how much gets into the bloodstream. Avoiding these is ideal but ensuring adequate separation of these will help prevent interactions from occurring.

What are the most common side effects of Synthroid (Levothyroxine)?

The most common side effects of Synthroid (Levothyroxine) are related to supratherapeutic doses (too high). arrhythmias, myocardial infarction, dyspnea muscle spasm, headache, nervousness, irritability, insomnia, tremors are some of the symptoms you may experience. 

Can you drink coffee right after taking Synthroid (Levothyroxine)?

All food and drink, aside from water, should be separated from Synthroid (Levothyroxine) by at least 30 minutes to 1 hour as these can affect the absorption of the medication. 

Do you increase Synthroid (Levothyroxine) if TSH is high?

Generally, if your thyroid stimulating hormone (TSH) is elevated beyond a certain range, your physician will increase your Synthroid (Levothyroxine) dose. TSH is produced by your body in response to low levels of circulating thyroid hormone but given that your body has a dysfunction/inability to produce more thyroid hormone the TSH can accumulate given there is not an adequate response made by your body so additional supplementation is required. 

How long can you go without thyroid medication?

It is not advised to go without your thyroid medication as this may result in you reverting to symptoms of hypothyroidism. It will vary from person to person but the half-life (the time it takes for half of the medication to be cleared from your body) of Synthroid (Levothyroxine) is about 9 to 10 days.