Empagliflozin/Metformin Hydrochloride

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Empagliflozin, Metformin
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Empagliflozin, Metformin
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Empagliflozin, Metformin
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Empagliflozin, Metformin
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Empagliflozin, Metformin
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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on October 14, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Synjardy Coupon

Get $10 off order



* minimum order of $100

* Please note, these coupon codes listed here are one-time use and cannot be combined with other coupons or offers.

Order Online

How to buy Synjardy online?

To order Synjardy, call 1-800-828-4489 and speak to customer support or order online through Use the chat feature for customer support. Visit the “How to Order” page on for more information.

Is a prescription required?

Yes, a valid prescription from your doctor is required to obtain Synjardy. Synjardy is a prescription medication and therefore, can only be sold with a prescription. Proof of a prescription is required to process your order. The prescription can be  faxed (1-800-416-8019), emailed ([email protected]), or uploaded. Alternatively, we can reach out to your doctor to obtain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered is based on the directions and authorized quantity indicated on the prescription from your provider.

Is it safe to order Synjardy from 90-Day Meds?

Absolutely. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medications through 90-Day Meds. Each of our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee.


Average US Retail Price 90-Day Meds Price
Synjardy 12.5 mg/1000mg
(60 tablets)
$658.25 $129.00

How much does Synjardy cost?

At, we make sure to keep drug prices low. You can view the Synjardy cost savings below:

We provide brand Synjardy 12.5 mg/1000 mg tablets here at 90-Day Meds. A quantity of 60 tablets of Synjardy costs $129, which comes out to $2.15 per unit.

Below shows the price comparison of Synjardy at a quantity of 60 tablets between the average U.S. retail price and 90-Day Meds price.

What is the lowest price of Synjardy per unit?

Lowest Price Per Unit: $1.82/unit for Synjardy 12.5 mg/1000 mg tablets

Is this price for Synjardy without insurance?

The prices mentioned above are without insurance. Although we cannot accept insurance, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Why is Synjardy cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries.


Sorry, we do not have a Synjardy (Empagliflozin/Metformin Hydrochloride) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.

Is there a coupon for Synjardy available?

Yes, we do you have a Synjardy coupon for an extra discount on your prescription. You can save $10 off your order with coupon code SYNJARDY10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.


Is there a lower cost generic Synjardy available?

Synjardy is not available as a generic alternative

How much cheaper is generic Synjardy?

There is currently no generic alternative to Synjardy.

What is the difference between brand and generic Synjardy?

Once available on the market, there will be no difference between generic and brand Synjardy. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

To see which prescriptions we have on file, sign into your account and view your previous orders. Placing a refill order online is made easy by accessing the reorder section in your account. The live chat is also a great place to connect with us to place a refill order while you are on the go. You can also call us and speak to customer support to place a refill.

Are prescriptions automatically refilled?

Prescriptions are not able to be automatically refilled since there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email when it is time to place a refill order based on your prescription fill history.

Drug Information


What is Synjardy?

Synjardy is a prescription medication that is classified as a combination product containing a sodium-glucose co-transporter 2 (SGLT-2) inhibitor (empagliflozin) and a biguanide (metformin).


What is Synjardy used for?

It is used in adjunct with diet and exercise to achieve glycemic control in patients with type 2 diabetes that were unresponsive to empagliflozin or metformin monotherapy.

How does it work?

The empagliflozin component inhibits SGLT2 which reduces the renal reabsorption of glucose resulting in increased glucose excretion. The metformin component increases peripheral glucose uptake and utilization to exert its glucose lowering effects.


How do I take Synjardy?

Synjardy should be taken as directed by your doctor. It should be dosed with meals to lessen the chance of stomach upset. While taking this medication, check your blood sugar regularly; your doctor will also monitor your blood sugar through blood tests periodically. You may also need to take other diabetes medications along with Synjardy, refer to your doctor for your specific diabetes management plan.

What dosages are available?

Synjardy is available by brand-only 5 mg/500 mg, 5 mg/1000 mg, 12.5 mg/500 mg, and 12.5 mg/1000 mg tablets.

What is the recommended dosage?

The specific dosage formulation of Synjardy depends on how controlled your diabetes was on your previous diabetes medications but generally it is dosed twice daily with meals.

What is the maximum dosage?

The maximum recommended dosage is 12.5 mg/1000 mg twice daily.

What if I miss a dose?

Take the missed dose as soon as you remember unless it is close to the time you are due for your next dose. If that is the case, just wait until it is time for your next dose. Do not double your dose to compensate for your missed dose.


What should you know before you take Synjardy?

Avoid excessive alcohol use and use in patients with hepatic impairment or in hypoxic states as it may result in lactic acidosis

This medication may result in hypotension. Patients should be assessed for appropriate volume status prior to therapy.

Renal function should be monitored during therapy

Discontinue Synjardy temporarily if patient is to undergo radiologic studies requiring iodinated contrast materials or if surgery requires restriction of food and fluid intake

The risk for hypoglycemia is increased if Synjardy is combined with insulin products; the dose of insulin may need to be lowered

Risk for genital mycotic infections, urinary tract infections, and vitamin B-12 deficiency

Synjardy may increase your LDL levels; your doctor will monitor and treat as appropriate

Currently there are no clinical studies to establish conclusive evidence that Synjardy has macrovascular risk reduction

Side Effects

What are the side effects of Synjardy?

Some common side effects (≥5%) include:

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Use caution with cationic drugs that are eliminated by renal tubular secretion as they may reduce the elimination of metformin


How should this medication be stored?

Keep Synjardy in the original container and store it in a dry place at room temperature 15-30°C (59-86°F).

Pharmacist Tips

  •  Symptoms of lactic acidosis include: feeling very weak/tired, unusual muscle pain, trouble sleeping, cold sensations in your arms and legs, and slow heartbeat. If you experience any of these symptoms, immediately seek medical attention.
  • There is a higher risk for experiencing lactic acidosis if you have renal impairment, liver impairment, have congestive heart failure, binge-drink alcohol, are dehydrated, have a history of heart attack, or are over the age of 80.
  • Symptoms of hypoglycemia include: fatigue, sweating, fast heartbeat, hunger, irritability, and confusion. If you experience any of these symptoms, check your blood sugar.


When is the best time to take Synjardy?

It should be taken twice daily whenever it fits best in your schedule. Taking your doses at the same time each day can help minimize missed doses.

Does Synjardy cause itching?

Itching is not a common side effect of Synjardy and may be an indication that you are allergic to a component of Synjardy. Let your doctor know if you experience itching or other allergy symptoms after taking Synjardy.

Can you take Synjardy and Metformin together?

It is not advised to take the two together as metformin is contained in Synjardy. Combining these medications may increase the chance of side effects with metformin.

Can Synjardy cause low blood pressure?

Yes. Patients that are dehydrated, elderly, or have renal impairment may be more likely to experience drops in blood pressure. Use caution when going from laying down to sitting or standing up to prevent falls and injuries.

Can I drink alcohol while taking Synjardy?

Avoid drinking excessive quantities of Synjardy as it may increase your risk for lactic acidosis. Try and limit to drinks daily for men and 1 drink daily for women.


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.