Brimonidine Tartrate/Brinzolamide

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Brimodine Tartrate / Brinzolamide (Generic)
Brinzolamide, Brimonidine Tartrate
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Brinzolamide, Brimonidine Tartrate
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Brinzolamide, Brimonidine Tartrate
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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on October 14, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Simbrinza Coupon

Get $10 off order



* minimum order of $100

* Please note, these coupon codes listed here are one-time use and cannot be combined with other coupons or offers.

Order Online

How to buy Simbrinza online?

To order Simbrinza, call 1-800-828-4489 and speak to customer support or order online through Use the chat feature for customer support. Visit the “How to Order” page on for more information.

Is a prescription required?

Yes, customers need a valid prescription from a doctor to obtain Simbrinza via 90-Day Meds as it is a prescription medication. You will need to provide a prescription to process your order. The prescription can be faxed (1-800-416-8019), emailed, or uploaded. Alternatively, we can reach out to your doctor to obtain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered at one time is based on the directions and authorized quantity indicated on the original prescription written by your provider.

Is it safe to order medication online from 90-Day Meds?

Absolutely. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medications. Each of our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee.


Average US Retail Price 90-Day Meds Price
Simbrinza 1%/0.2%
$217.34 (8 mL) $104.00

How much does Simbrinza cost?

At, we make sure to keep drug prices low. You can view the Simbrinza cost savings below:

We provide brand Simbrinza 1%/0.2% ophthalmic suspension here at 90-Day Meds. A quantity of 1 bottle (10 mL) of Simbrinza costs $104, which comes out to $10.40 per unit.

Below shows the price comparison of brand Simbrinza at a quantity of 10 mL between the average U.S. retail price and 90-Day Meds price.

What is the lowest price of Simbrinza per unit?

Lowest Price Per Unit: $9.00/unit for brand Simbrinza 1%/0.2% ophthalmic suspension

Is this price for Simbrinza without insurance?

The prices mentioned above are not processed through insurance as we are unable to process insurance claims. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Why is Simbrinza cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada. Because the US is a free market economy, the price differs since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we supply medications from these countries. 


Sorry, we do not have a Simbrinza (Brimonidine Tartrate/Brinzolamide) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.

Is there a coupon for Simbrinza available?

Yes, we do you have a Simbrinza coupon for an extra discount on your prescription. You can save $10 off your order with coupon code SIMBRINZA10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.


Is there a lower cost generic Simbrinza available?

Simbrinza is not available as a generic alternative.

How much cheaper is generic Simbrinza?

There is currently no generic alternative available.

What is the difference between brand and generic Simbrinza?

Once available on the market, there will be no difference between generic and brand product. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

90-Day Meds makes refilling your prescriptions fast and easy. To see which prescriptions we have on file, sign into your account and view your previous orders then simply access the reorder section in your account to order a refill on your prescription(s). The live chat is also a great place to connect with us to place a refill order while you are on the go. You can also call us and speak to customer support to place a refill.

Are prescriptions automatically refilled?

Prescriptions may not be automatically refilled as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email when it is time to place a refill order based on your prescription fill history.

Drug Information


What is Simbrinza?

Simbrinza is a prescription medication that is classified as a combination product that contains a carbonic anhydrase inhibitor and an alpha-2 adrenergic receptor agonist.


What is Simbrinza used for?

It is used to reduce elevated intraocular pressure in patients diagnosed with open-angle glaucoma and/or ocular hypertension.

How does it work?

Brinzolamide is the carbonic anhydrase inhibitor that decreases aqueous humor secretion by slowing down the formation of bicarbonate ions. Brimonidine reduces the production of aqueous humor and increases uveoscleral outflow. The combination of these products together decrease intraocular pressure.


How do I take Simbrinza?

Take this medication as directed by your doctor. Wash your hands before and after use and make sure not to touch the tip of the dropper to your eye. Shake the bottle well before each use to ensure the medication is properly suspended prior to administration. If you wear contact lenses, remove prior to administration and wait at least 15 minutes before reinserting. If you are taking other eye drops, wait at least 5 minutes until administering.

What dosages are available?

It is available as a brand 1%/0.2% ophthalmic suspension.

What is the recommended dosage?

Typically one drop is instilled into each affected eye(s) three times daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 3 drops into the affected eye(s) per day.

What if I miss a dose?

If you miss a dose of this medication, take your dose as soon as you remember unless it is time for your next scheduled dose. In that case, just take your scheduled dose and skip your missed dose but do not double your dose to compensate.


What should you know before you take Simbrinza?

There is a risk of corneal endothelium cell loss

It is not recommended in patients with a CrCl <30 mL/min (severe renal impairment) due to the lack of efficacy and safety data available in these patients
Because brinzolamide is a sulfonamide, Simbrinza may cause sulfonamide hypersensitivity reactions which can lead to serious complications such as Stevens-Johnson syndrome. Discontinue if a serious reaction occurs.
Bacterial keratitis may occur secondary to accidental contamination of multiple-dose ophthalmic solutions

Side Effects

What are the side effects of Simbrinza?

Some common side effects (≥ 3 – 5%) include:

  • Blurred vision
  • Eye irritation
  • Dysgeusia (bad taste)
  • Dry mouth
  • Eye allergy

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Known drug interactions with Simbrinza include medications in the following classes: central nervous system depressants, tricyclic antidepressants, monoamine oxidase inhibitors, antihypertensives, oral carbonic anhydrase inhibitors, and high-dose salicylate therapy.


How should this medication be stored?

Keep Simbrinza in the original container and store it in a dry place at room temperature 2 – 25°C (36 – 77°F).

Pharmacist Tips

  • Contact lenses should be removed prior to Simbrinza administration. 15 minutes post Simbrinza administration, you may reinsert lenses.
  • Make sure to keep the cap closed when not using Simbrinza and to avoid touching the tipper to the surface of the eye to prevent bacteria from entering the prescription bottle.
  • Simbrinza may cause fatigue and/or drowsiness, you should avoid hazardous activities such as driving until you know how Simbrinza will affect you.
  • Do not use past the expiration date printed on the bottle.


What signs should I look out for when taking Simbrinza?

When taking Simbrinza, you should look out for any signs of allergic reactions such as rashes, wheezing, tightness in chest, difficulty breathing, or face swelling.

What should I do if I miss my dose of Simbrinza?

Use Simbrinza as soon as you remember you missed a dose. If it is almost time for your next dose, only take one dose. It is important to not take two doses of Simbrinza at the same time.

Can I wear contact lenses while taking Simbrinza?

Contact lenses should be removed prior to SImbrinza administration. You may reinsert your contact lens after 15 minutes.

Does Simbrinza cause low blood pressure?

Simbrinza contains brimonidine which may lower blood pressure. In studies, Simbrinza had less than a 5% mean decrease in blood pressure 2 hours after administration. Exercise caution if you are taking any antihypertensives or cardiac glycosides.

Is it possible to lose hair when on Simbrinza?

Hair loss is not a reported side effect of Simbrinza.


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.