Rexulti

Brexpiprazole

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Rexulti
Brexpiprazole
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Doctor

Medically reviewed by: Samuel Maaiah

Last updated on August 18, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

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How to buy Rexulti (brexpiprazole) online?

Rexulti (Brexpiprazole) can be ordered by calling 1-800-828-4489 and speaking to customer support or online through 90daymeds.com. The chat feature can also be used for support. For more information please visit the “How to Order” page on 90daymeds.com.

Is a prescription required?

Yes, Rexulti (Brexpiprazole) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. A valid prescription from your doctor is required. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider. Refills are kept on file for future orders.

Is it safe to order Rexulti (brexpiprazole) from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee.

Cost

Average US Retail Price 90-Day Meds Price
Rexulti 1 mg
(30 tablets)
$1,456.28 $634.00

How much does Rexulti (brexpiprazole) cost?

At 90DayMeds.com, we make sure to keep drug prices low. You can view the Rexulti (Brexpiprazole) cost savings above the price comparison of Rexulti (Brexpiprazole) between the average U.S. retail price and 90-Day Meds price.

What is the lowest price of Rexulti (Brexpiprazole) per unit?

Lowest Price Per Unit: $20.37/unit for Rexulti (Brexpiprazole) 1 mg tablets

Is this price for Rexulti (Brexpiprazole) without insurance?

The prices are not including insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt that you can use to apply for reimbursement with your insurer. We are also unable to adjudicate with US insurance providers.

Why is Rexulti (Brexpiprazole) cheaper from Canada than from the United States?

The cost of medications ordered from Canada are cheaper because their drug prices are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider to be appropriate for the medication. As a result, we can offer lower prices to our patients as we utilize medications from these countries.

Coupon

Sorry, we do not have a Rexulti (Brexpiprazole) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.

Generic

Is there a lower cost generic Rexulti (Brexpiprazole) available?

Rexulti (Brexpiprazole) is not available as a generic alternative.

How much cheaper is generic Rexulti (Brexpiprazole)?

There is currently no generic alternative to Rexulti (Brexpiprazole).

What is the difference between brand and generic Rexulti (Brexpiprazole)?

Once available on the market, there will be no difference between generic and brand Rexulti (Brexpiprazole). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.

Shipping

Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. Placing a refill order online is made simple by accessing the reorder section in your account. You can sign into your online account and view your previous orders and see which prescriptions we have on file.
You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information

About

What is Rexulti (Brexpiprazole)?

Rexulti (Brexpiprazole) is prescription medication that is classified as an atypical antipsychotic.

Uses

What is Rexulti used for?

It is used as an add-on therapy to antidepressants for the treatment of major depressive disorder (MDD) as well as for the treatment of schizophrenia.

How does it work?

It exerts its antidepressant effects by acting as a partial agonist at serotonin 5-HT-1A and dopamine D2 receptors, and as an antagonist at serotonin 5-HT-2A receptors.

Directions

How do I take Rexulti (Brexpiprazole)?

Take Rexulti (Brexpiprazole) as directed by your doctor. Taking it at the same time each day can help to avoid forgetting doses.

What dosages are available?

Rexulti (Brexpiprazole) is available as brand 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg tablets.

What is the recommended dosage?

Generally it is dosed 1 mg once daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 4 mg/day.

What if I miss a dose?

If you miss a dose take it as soon as you remember, if it is relatively close to the time of your next dose wait until then and take a regular dose. Do not take 2 doses of Rexulti (Brexpiprazole) at the same time.

Precautions

What should you know before you take Rexulti (Brexpiprazole)?

There is an increased risk of mortality in elderly patients with dementia related psychosis when taking antipsychotic drugs (class related).

There is a chance that this medication can increase the risk of suicidal thoughts and behaviors in patients who are 24 and younger in short term studies. Rexulti (Brexpiprazole) has not been studied in pediatric patients.

Increased risk for cerebrovascular accidents in elderly patients with dementia-related psychosis in placebo controlled trials with 2nd generation antipsychotic medications. (class related)

Patients with existing diabetes should exercise caution while taking this medication as it can cause hyperglycemia and in some extreme cases can be associated with ketoacidosis.

Atypical antipsychotics can exacerbate dyslipidemia in some patients so it is important to have a baseline lipid profile completed as well as routine monitoring there after.

A post marketing analysis reports that some patients experience increased urges, significantly in regards to gambling, and an inability to manage and control these urges. Make sure you talk to your doctor if you start to experience compulsive urges.

Patients with that are CYP2D6 poor metabolizers should inform their doctor as this prompts an alteration in the recommended dose.

Side Effects

What are the side effects of Rexulti (Brexpiprazole)?

Some common side effects include:

  • Metabolic changes
  • Orthostatic Hypotension
  • Neuroleptic Malignant Syndrome
  • Tardive Dyskinesia
  • Body Temperature Dysregulation
  • Cognitive and Motor Impairment

Speak to your doctor for a full list of side effects.

Interactions

Does this medication interact with other drugs, foods, or alcohol?

Rexulti (Brexpiprazole) is mainly metabolized by CYP3A4 and CYP2D6, as a result, medications that are strong inhibitors/inducers of these enzymes should be identified and dosing should be adjusted accordingly. Some examples are listed below.

  • Strong CYP3A4 Inhibitors: itraconazole, clarithromycin, ketoconazole
  • Strong CYP2D6 Inhibitors: paroxetine, fluoxetine, quinidine
  • Strong CYP3A4 Inducers: rifampin, St. John’s wort
    Dose adjustment recommendations are listed in the package label

Storage

How should this medication be stored?

Rexulti (Brexpiprazole) should be stored at 20°C to 25°C (68°F to 77°F)

Pharmacist Tips

  • If you notice any negative changes in your mood while taking Rexulti (Brexpiprazole) notify your doctor.
  • Can be taken with or without food
  • Call your health care provider immediately if you experience high fever, stiff muscles, confusion, sweating, changes in pulse, heart rate, and blood pressure.
  • Inform your doctor if you have a history of diabetes, high/low blood pressure, seizures, strokes, a low white blood cell count, or if you are pregnant or may become pregnant.

FAQ

Does Rexulti (Brexpiprazole) cause low white blood cell count?

Neutropenia/leukopenia have been reported with other antipsychotic agents within the same class as Rexulti (Brexpiprazole), if you notice signs and symptoms of an infection make sure and notify your provider as soon as possible. If you develop a white count <1000 cells/mm3 your provider will likely discontinue the medication until it returns to normal.

What is Rexulti (Brexpiprazole) approved for?

Per the manufacturer and FDA, Rexulti (Brexpiprazole) is approved as an adjunctive treatment for major depressive disorder and for schizophrenia.

Does Rexulti (Brexpiprazole) make you hungry?

During the clinical trials 3% of patients reported having an increased appetite.

Does Rexulti (Brexpiprazole) help with anxiety?

In the clinical trials the study participants for MDD had MDD with or without anxiety and their improvement was based on the change in their MADRS score. This scoring system does have an anxiety component. Rexulti (Brexpiprazole) is not indicated for anxiety. Approximetly 3% of the study population reported anxiety as an adverse event.

Is Rexulti (Brexpiprazole) addictive?

No, Rexulti (Brexpiprazole) has little habit forming potential, in the studies Rexulti (Brexpiprazole) did not demonstrate any withdrawal signs upon discontinuation, talk to your doctor first before deciding to discontinue Rexulti (Brexpiprazole).