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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on August 18, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.

Pentasa Coupon

Get $10 off order



* minimum order of $100

* Please note, these coupon codes listed here are one-time use and cannot be combined with other coupons or offers.

Order Online

How to buy Pentasa (Mesalamine) online?

Pentasa (Mesalamine) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on

Is a prescription required?

Yes, a valid prescription from your doctor is required. Pentasa (Mesalamine) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor.

Is it safe to order Mesalamine from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Pentasa Cost

Average US Retail Price 90-Day Meds Price
Pentasa 500mg $921.72
(120 tablets)
( 100 tablets)

How much does Pentasa (Mesalamine) cost?

At, we make sure to keep drug prices low.

You can view the Pentasa (Mesalamine) cost savings above with price comparison of Pentasa (Mesalamine) between the average U.S. retail price and 90-Day Meds price.

What is the lowest price of Pentasa (Mesalamine) per unit?

Lowest Price Per Unit: $0.41/unit for Pentasa (Mesalamine) 500mg tablets 

Is this price for Pentasa (Mesalamine) without insurance?

The prices listed are without insurance. Unfortunately, we can’t accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Pentasa (Mesalamine) cheaper from Canada than from the United States?

Drug prices in Canada are negotiated and regulated. The US is a free market economy which is why the price may differ since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries.

Pentasa Coupon

Sorry, we do not have a Pentasa (Mesalamine) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.

Is there a coupon for Pentasa available?

Yes, we do you have a Pentasa coupon for an extra discount on your prescription. You can save $10 off your order with coupon code PENTASA10. Apply coupon at checkout for instant savings and pay less for your prescription with a minimum $100 order.


Is there a lower cost generic Mesalamine available?

Pentasa (Mesalamine) is not available as a generic alternative.

How much cheaper is generic Pentasa (Mesalamine)?

There is currently no generic alternative.

What is the difference between brand and generic Pentasa (Mesalamine)?

Once available on the market, there will be no difference between generic and brand Pentasa. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

Standard shipping is free.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Pentasa (Mesalamine)?

Pentasa (Mesalamine) is a prescription medication that is classified as an 5-aminosalicylic acid derivative.


What is Pentasa used for?

It is indicated for the treatment and maintenance of mild-to-moderately active ulcerative colitis in adults.

How does it work?

It reduces inflammation by inhibiting prostaglandin and cyclooxygenase synthesis in the colon.


How do I take Pentasa (Mesalamine)?

Take your Pentasa (Mesalamine) tablet whole by mouth with or without food. Do not crush, cut, or chew the capsule. Take as directed by your doctor.

What dosages are available?

Pentasa (Mesalamine) is available as a brand in 250mg and 500mg capsules (dosage forms in the U.S.) and 100 mg and 1000 mg ER tablets (dosage forms in Canada).

What is the recommended dosage?

It is typically dosed 1g four times daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 4g/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.


What should you know before you take Pentasa (Mesalamine)?

Caution in patients predisposed to pericarditis and myocarditis.

Mesalamine-induced hypersensitivity reactions have been reported. 

Intolerance syndrome (bloody diarrhea, ramping, abdominal pain) may occur with Pentasa (Mesalamine) use.

Caution in patients with pre-existing skin conditions as severe photosensitivity reactions have been reported with use.

A renal evaluation should be done prior to starting Pentasa (Mesalamine).

Patients with a hypersensitivity to sulfasalazine can react to Pentasa (Mesalamine).

Side Effects

What are the side effects of Pentasa (Mesalamine)?

Some common side effects include:

  • Abdominal pain, constipation, eructation
  • Headache 
  • nasopharyngitis 

Speak to your doctor for a full list of side effects that apply to you if you are taking Pentasa (Mesalamine).


Does this medication interact with other drugs, foods, or alcohol?

Antacids can decrease the therapeutic effect of Pentasa (Mesalamine) (Risk Category D).

Avoid administration of salicylates for at least 6 weeks after a varicella-virus containing vaccine has been administered (Risk Category D).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

Store your Pentasa (Mesalamine) at 25˚C (77˚F).  Excursions are allowed to be stored between 15-30˚C (59-86˚F).

Pharmacist Tips

  • Do not crush, cut, or chew the tablet.
  • Avoid taking antacids with Mesalamine as it can decrease the therapeutic effect of your medication
  • If you develop any hypersensitivity reactions, stop the medication and seek medical help.


Is Pentasa (Mesalamine) an immunosuppressant?

No. Pentasa (Mesalamine) is a 5-aminosalicylic acid derivative.

What type of drug is Pentasa (Mesalamine)?

Pentasa (Mesalamine) is a 5-aminosalicylic acid derivative.

Is Pentasa (Mesalamine) a corticosteroid?

No. Pentasa (Mesalamine) is a 5-aminosalicylic acid derivative.

Is Pentasa (Mesalamine) a biologic?

No. Pentasa (Mesalamine) is a 5-aminosalicylic acid derivative.

Does Pentasa (Mesalamine) cause weight gain?

Mesalamine can cause weight loss in children and adolescents.


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.