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Medically reviewed by: Samuel Maaiah

Last updated on August 18, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.


Order Online

How to buy Nexium (Esomeprazole) online?

Nexium (Esomeprazole) can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on 

Is a prescription required?

For this dose of Nexium (Esomeprazole), yes, a valid prescription from your doctor is required. Nexium (Esomeprazole)  40 mg tablet is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider.

Is it safe to order Nexium (Esomeprazole) from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.


Average US Retail Price 90-Day Meds Price
Nexium 40 mg DR $923.00
(90 capsules)
(84 tablets)
Esomeprazole 40 mg DR $696.60
(90 capsules)
(84 tablets)

How much does Nexium (Esomeprazole) cost?

At, we make sure to keep drug prices low. You can view the Nexium (Esomeprazole)  cost savings above with the price comparison of brand and generic Nexium (Esomeprazole) between the average U.S. retail price and 90-Day Meds price

What is the lowest price of Nexium (Esomeprazole) per unit?

Lowest Price Per Unit: $0.40/unit for generic Nexium (Esomeprazole) 40 mg tablets.

Is this price for Nexium (Esomeprazole) without insurance?

The listed prices are without insurance. Unfortunately, we do not accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurance company. We are unable to adjudicate with US insurance providers.

Why is Nexium (Esomeprazole) cheaper from Canada than from the United States?

Drug prices in Canada and some other countries are negotiated and regulated. The US is a free market economy which is why the price may differ since pharmaceutical suppliers can charge what they determine to be appropriate for the product. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 



Sorry, we do not have a Nexium (Esomeprazole) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.


Is there a lower cost generic Nexium (Esomeprazole) available?

Nexium (Esomeprazole)  is available as a generic alternative.

How much cheaper is generic Nexium (Esomeprazole)?

Generic Nexium (Esomeprazole) is $65 cheaper than brand Nexium at a quantity of 84 tablets.  

What is the difference between brand and generic Nexium (Esomeprazole)?

There is no difference between generic and brand Nexium (Esomeprazole). Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Nexium (Esomeprazole)?

Nexium (Esomeprazole) is a prescription medication that is classified as a proton pump inhibitor (PPI).


What is it used for?

The tablet formulation (prescription only) is indicated for the treatment of gastroesophageal reflux disease. 

How does it work?

It inhibits the final step in acid production which suppresses gastric acid secretion. 


How do I take Nexium (Esomeprazole) ?

Take your Nexium (Esomeprazole)  tablet by mouth with a full glass of water in the morning before breakfast.Do not chew, cut, or crush the tablet. Remain upright for at least 30 minutes after taking the dose. 

What dosages are available?

Nexium (Esomeprazole)  is available as a brand or generic tablet. Nexium (Esomeprazole)  40 mg delayed release tablet is available from Canada as a brand and generic.

What is the recommended dosage?

It is typically dosed 20 mg once daily but take as directed by your doctor.

What is the maximum dosage?

The maximum recommended dosage is 40 mg/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.



What should you know before you take Nexium (Esomeprazole)?

Closteriodioides (formally known as Clostridium) difficile-associated diarrhea (CDAD) may occur with long-term use of a PPI, especially in hospitalized patients.

Cutaneous and systemic lupus erythematosus has been reported with use (new onset or exacerbation). 

Increased incidence of osteoporosis-related bone fractures of the wrist, hip, or spine can occur with  use of PPI. 

Use of PPIs increases the risk of fundic gland polyps, especially long term use (>1 year).  

Gastrointestinal infections are increased with PPIs. 

Hypomagnesemia, although rarely reported, can occur with prolonged use of PPI therapy (3 months +). 

Vitamin B12 deficiency can occur with prolonged use of PPIs (2 years +) due to vitamin B12 malabsorption. 

Acute tubular nephritis has been observed in those taking PPIs and can occur at any time. 

Side Effects

What are the side effects of Nexium (Esomeprazole)?

Some common side effects include:

  • Headache
  • Increased risk of infection

Speak to your doctor for a full list of side effects that apply to you if you are taking Nexium (Esomeprazole).


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with acalabrutinib, cefuroxime, strong CYP2C19 inducers, dacomitinib, delavirdine, erlotinib, infigratinib, neratinib, pazopanib, pexidartinib, rilpivirine, sotorasib, or St. John’s wort (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

Your Nexium (Esomeprazole)  should be stored at 25°C (77°F). Excursions are allowed to be stored between 15 to 30°C (59 to 86°F)

Pharmacist Tips

  • Prolonged treatment (2 years+) may lead to vitamin B12 deficiency.
  • Take your Nexium (Esomeprazole)  tablet whole with a full glass of water before breakfast. Do not chew, crush, or cut your tablet.


Is Nexium (Esomeprazole) over the counter?

There are some formulations of Nexium (Esomeprazole)  that are available over the counter. 

Is Nexium (Esomeprazole) an antacid?

Nexium (Esomeprazole)  is a PPI.

Is it safe to take Nexium (Esomeprazole) everyday?

Long-term use of a PPI can increase the risk of adverse events. Speak with your provider if you plan on taking Nexium (Esomeprazole)  everyday. 

Is Nexium (Esomeprazole) the same as omeprazole?

Nexium (Esomeprazole)  is the brand of esomeprazole. Esomeprazole and omeprazole belong to the same drug class, PPI.

Does Nexium (Esomeprazole) contain ranitidine?

No. The only active ingredient in Nexium (Esomeprazole)  is esomeprazole.