Kombiglyze XR

Saxagliptin Hydrochloride/Metformin Hydrochloride

Select your dosage below to view Kombiglyze XR cost and place your order. Save up to 90% and get FREE standard shipping on prescription medication delivered to your door.

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90 Day Meds Questions
Kombiglyze XR
Saxagliptin Hydrochloride, Metformin Hydrochloride
Select product strength & quantity:
Select product strength & quantity:
Kombiglyze XR
Saxagliptin Hydrochloride, Metformin Hydrochloride
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on August 18, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.


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How to buy Kombiglyze XR (Saxagliptin and Metformin) online?

Kombiglyze XR can be ordered online through 90daymeds.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on 90daymeds.com.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Kombiglyze XR is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor.

Is it safe to order online from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.


Average US Retail Price 90-Day Meds Price
Kombiglyze XR 2.5mg/1000mg
(56 tablets)
(60 tablets)

How much does Kombiglyze XR cost?

Above shows the price comparison between the average U.S. retail price and 90-Day Meds price of Kombiglyze XR 2.5 mg/1000 mg.

At 90DayMeds.com, we make sure to keep drug prices low and cost savings are significant. 

What is the lowest price of Kombiglyze XR per unit?

Lowest Price Per Unit: $2.23/unit for Kombiglyze XR 2.5 mg/1000mg tablets 

Is this price for Kombiglyze XR without insurance?

The listed prices are not processed through insurance. Unfortunately, we cannot accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer since we are also unable to adjudicate with US insurance providers.

Why is Kombiglyze XR cheaper from Canada than from the United States?

Drug prices in Canada and some other countries are negotiated and regulated. The US is a free market economy which is how the price can differ since pharmaceutical suppliers can charge what they deem appropriate for the product. As a result, we offer lower prices to our patients as we supply medications from these countries.


Sorry, we do not have a Kombiglyze XR (Saxagliptin Hydrochloride/Metformin Hydrochloride) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.


Is there a lower cost generic Kombiglyze XR available?

There currently is no generic option available on the market.

How much cheaper is generic Kombiglyze XR?

Generic drugs are often much cheaper and affordable. There is currently no generic alternative available.

What is the difference between brand and generic Kombiglyze XR?

Once available on the market, there will be no difference between generic and brand Kombiglyze XR. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States. 

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.
You can also call us at 1-800-828-4889 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Kombiglyze XR?

Kombiglyze XR is a prescription medication that is classified as a combination product containing a dipeptidyl peptidase 4 (DPP-4) inhibitor (saxagliptin) and a biguanide (metformin). 


What is Kombiglyze XR used for?

It is used for the treatment of type 2 diabetes mellitus.

How does it work?

The saxagliptin component inhibits DPP4 which allows for increased levels of glucagon-like peptide-1 (GLP-1) which lower glucose levels in a glucose-dependent manner. Metformin increases glucose uptake and utilization to lower blood glucose levels.


How do I take Kombiglyze XR?

Take your tablet whole by mouth once daily with evening meals as directed by your doctor. Do not chew or crush the tablet.

What dosages are available?

Kombiglyze XR is available only as a brand with the saxagliptin component being immediate release and the metformin component being extended release (2.5mg/1000mg; 5mg/500mg; 5mg/1000mg).

What is the recommended dosage?

The specific dosing varies based on patient-specific factors, refer to your doctor for dosing recommendations.

What is the maximum dosage?

The maximum recommended dosage is 5mg saxagliptin/2000mg metformin per day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the dose.


What should you know before you take Kombiglyze XR?

Severe/disabling arthralgia has been reported with DPP-4 inhibitors. Onset can occur within a day to years after starting therapy. 

Bullous pemphigoid development has been associated with DPP-4 inhibitors.

Acute pancreatitis cases have been reported with use. 

Caution in renal function. Dose adjustment/discontinuation of therapy may be needed.

  • eGFR > 45 mL/minute/1.73m2: No dose adjustment needed. 
  • eGFR 30 to 45 mL/minute/1.73m2:
    • Initiation: Not recommended.
    • Continuation: A metformin dose reduction of 50% is needed (maximum 1 g/day) and limit saxagliptin dose to 2.5 mg/day. 
  • eGFR < 30 mL/minute/1.73m2: Use is contraindicated. 

If acute kidney injury occurs during therapy, the patient should hold the medication due to the metformin component.

Vitamin B12 deficiency has been associated with long-term metformin use. Vitamin B12 serum concentrations should be periodically monitored with long-term therapy.

U.S. Boxed Warning: Metformin-induced lactic acidosis have been reported in postmarketing cases that have resulted in death. The risk is increased with renal dysfunction.

Side Effects

What are the side effects of Kombiglyze XR?

Some common side effects include:

  • Abdominal pain, diarrhea, nausea
  • Headache
  • Upper respiratory tract infection

Speak to your doctor for a full list of side effects that apply to you if you are taking Kombiglyze XR.


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with alcohol due to increased risk of lactic acidosis with metformin (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

Janumet XR should be stored between 20-25°C (68-77°F). Excursions are allowed to be stored between 15-30°C (59-86°F).

Pharmacist Tips

  • Take with food to decrease the risk of any gastrointestinal side effects due to the metformin component of the medication. 
  • Do not chew or crush the tablet. 


Is Kombiglyze XR insulin?

No. Kombiglyze XR is composed of saxagliptin (DDP-4 inhibitor) and metformin (biguanide).

How does Kombiglyze XR work in the body?

Kombiglyze XR works by decreasing the amount of sugar your liver releases in your body and increases your body’s insulin sensitivity.

What class of drug is Kombiglyze XR?

Kombiglyze XR is made up of two drug classes, a DDP-4 inhibitor and biguanide.

Does Kombiglyze XR cause weight gain?

No. Weight gain is not a listed side effect of Kombiglyze XR.

What is Kombiglyze XR used for?

Kombiglyze XR is used for the treatment of type 2 diabetes mellitus.


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.