Linagliptin/Metformin Hydrochloride

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Linagliptin, Metformin Hydrochloride
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Linagliptin, Metformin Hydrochloride
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Metformin Hydrochloride, Linagliptin
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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on August 18, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.


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Order Online

How to buy Jentadueto online?

Jentadueto can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on 

Is a prescription required?

Yes, a valid prescription from your doctor is required. Jentadueto is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor

Is it safe to order online from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Jentadueto Cost

Average US Retail Price 90-Day Meds Price
Jentadueto 2.5mg/1000mg
(180 tablets)
$1664.00 $597.00

How much does Jentadueto cost?

Above shows the price comparison between the average U.S. retail price and 90-Day Meds price of Jentadueto 2.5 mg/1000mg. 

At, we make sure to keep drug prices low. 

We provide Jentadueto 2.5mg/1000mg tablets here at 90-Day Meds at discount prices. A quantity of 180 tablets of Jentadueto costs $597, which comes out to $3.32 per unit.

What is the lowest price of Jentadueto per unit?

Lowest Price Per Unit: $2.95/unit for Jentadueto 2.5mg/1000mg tablets 

Is this price for Jentadueto without insurance?

The listed prices are not including insurance. Unfortunately, we do not accept insurance. However, we will give you an itemized receipt which you can use to apply for reimbursement with your insurer. We are also unable to process claims with US insurance providers.

Why is Jentadueto cheaper from Canada than from the United States?

Drug prices are negotiated and regulated in Canada and from other countries we source medication. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for the product. As a result, we offer lower prices to our patients as we utilize medications from these countries. 

Jentadueto Coupon

Sorry, we do not have a Jentadueto (Linagliptin/Metformin Hydrochloride) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.


Is there a lower cost generic Jentadueto available?

Jentadueto is not available as a generic alternative. 

How much cheaper is generic Jentadueto?

Generic drugs are often much cheaper than their brand name counterpart. There is currently no generic alternative to Jentadueto.  

What is the difference between brand and generic Jentadueto?

Once available on the market, there will be no difference between generic and brand Jentadueto. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States. 

How much does shipping cost?

There are no standard shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us at 1-800-828-4889 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Jentadueto?

Jentadueto is a prescription medication that is classified as a combination product that contains a dipeptidyl peptidase 4 (DPP-4) inhibitor (linagliptin) and a biguanide (metformin). 


What is Jentadueto used for?

It is used for the treatment of type 2 diabetes mellitus.

How does it work?

The Linagliptin component inhibits DPP4 which allows for increased levels of glucagon-like peptide-1 (GLP-1) and lower glucose levels in a glucose-dependent manner. Metformin increases glucose uptake and utilization to lower blood glucose levels.  


How do I take Jentadueto?

Take your Jentadueto tablet by mouth with food at the same time(s) daily as directed by your doctor.

What dosages are available?

Jentadueto is available as a brand only as either an immediate release or extended release tablet:

  • IR: 2.5mg/500mg, 2.5mg/850mg, 2.5mg/1000mg tablets.
  • XR: 2.5mg/1000mg, 5mg/1000mg tablets.

What is the recommended dosage?

The recommended dose varies based on patient-specific factors, for questions about dosing refer to your doctor.

What is the maximum dosage?

The maximum recommended dosage is 5mg linagliptin/2000mg metformin per day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the dose.


What should you know before you take Jentadueto?

Severe/disabling arthralgia has been reported with DPP-4 inhibitors. Onset can occur within a day to years after starting therapy.

Bullous pemphigoid development has been associated with DPP-4 inhibitors.

Vitamin B12 deficiency has been associated with long-term metformin use. Vitamin B12 serum concentrations should be periodically monitored with long-term therapy.

Acute pancreatitis cases have been reported with use. 

Caution in renal function. Dose adjustment/discontinuation of therapy may be needed.

  • eGFR > 45 mL/minute/1.73m2: No dose adjustment needed. 
  • eGFR 30 to 45 mL/minute/1.73m2:
    • Initiation: Not recommended.
    • Continuation: A metformin dose reduction of 50% is needed (maximum 1 g/day) and renal monitoring every 3 months is recommended. 
  • eGFR < 30 mL/minute/1.73m2: Use is contraindicated. 

U.S. Boxed Warning: Metformin-induced lactic acidosis have been reported in postmarketing cases that have resulted in death. The risk is increased with renal dysfunction.

Side Effects

What are the side effects of Jentadueto?

Some common side effects include:

  • Diarrhea
  • Nasopharyngitis

Speak to your doctor for a full list of side effects that apply to you if you are taking Jentadueto.


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with alcohol due to increased risk of lactic acidosis with metformin (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions. 


How should this medication be stored?

Jentadueto should be stored between 25°C (77°F). Excursions are allowed to be stored between 15°-30°C (59°-86°F). Avoid exposure to high humidity. Keep out of reach of children.

Pharmacist Tips

  • Take with food to decrease the risk of any gastrointestinal side effects due to the metformin component of the medication.


Is Jentadueto the same as metformin?

No. Jentadueto is composed of both linagliptin and metformin.

Is Jentadueto the same as Janumet?

No. They both contain different DDP-4 inhibitors and metformin. Jentadueto is composed of both linagliptin and metformin while Janumet is composed of sitagliptin and metformin.

Is Jentadueto a SGLT2 inhibitor?

No. Jentadueto is made up of a dipeptidyl peptidase 4 (DPP-4) inhibitor (linagliptin) and a biguanide (metformin).

Is Jentadueto available as a generic?

No. Jentadueto is only available as a brand.

What is Jentadueto?

Jentadueto is dipeptidyl peptidase 4 (DPP-4) inhibitor (linagliptin) and a biguanide (metformin) and indicated for the treatment of type 2 diabetes mellitus.


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.