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Valsartan, Sacubitril
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How to buy Entresto online?

Entresto (Sacubitril/Valsartan) can be ordered online through 90daymeds.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on 90daymeds.com. 

Is a prescription required?

Yes, Entresto (Sacubitril/Valsartan) is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. A valid prescription from your doctor is required. The prescription can be emailed ([email protected]), uploaded, or faxed (1-800-416-8019). Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 90-day supply  is the maximum amount that can be ordered at one time. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your provider. Refills are kept on file for future orders.

Is it safe to order online from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. 


Average US Retail Price 90-Day Meds Price
Entresto (Sacubitril/Valsartan) 24/26 mg $653.00
(60 tablets)
(56 tablets)

How much does Entresto (Sacubitril/Valsartan) cost?

At 90DayMeds.com, we make sure to keep drug prices low. You can view the Entresto (Sacubitril/Valsartan) cost savings above.

What is the lowest price of Entresto (Sacubitril/Valsartan) per unit?

Lowest Price Per Unit: $4.29/unit for Entresto (Sacubitril/Valsartan) 24/26 mg tablets

Is this price for Entresto (Sacubitril/Valsartan) without insurance?

The listed prices above are without insurance. Unfortunately, we are unable to accept insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer. We are unable to adjudicate with US insurance providers.

Why is Entresto (Sacubitril/Valsartan) cheaper from Canada than from the United States?

Drug prices in Canada and from other countries we source medication from are negotiated and regulated. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for products. As a result, we can offer lower prices to our patients as we utilize medications from these countries. 


Sorry, we do not have a Entresto (Sacubitril/Valsartan) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.


Is there a lower cost generic Entresto (Sacubitril/Valsartan) available?

Entresto (Sacubitril/Valsartan) is not available as a generic alternative. 

How much cheaper is generic Entresto (Sacubitril/Valsartan)?

There is currently no generic alternative to Entresto. 

What is the difference between brand and generic Entresto (Sacubitril/Valsartan)?

Once available on the market, there will be no difference between generic and brand Entresto. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation. 


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. We ship nationwide across the United States.

How much does shipping cost?

There are no shipping fees.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign in to your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account. You can also call us at 1-800-416-8019 and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go. 

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Entresto (Sacubitril/Valsartan)?

Entresto is a combination prescription medication that is classified as a neprilysin inhibitor and angiotensin II receptor blocker (ARB).


What is Entresto used for?

Entresto (Sacubitril/Valsartan) is used to reduce the risk of cardiovascular death in patients with chronic heart failure and to help treat symptoms of heart failure.

How does it work?

It inhibits neprilysin which increases levels of natriuretic peptides and inhibits angiotensin-II dependent aldosterone release. 


How do I take Entresto (Sacubitril/Valsartan)?

You should take Entresto (Sacubitril/Valsartan) as instructed by your physician. It is important to note, your dose may need to be adjusted several times to find what works best for you.

What dosages are available?

Entresto (Sacubitril/Valsartan) is available as brand name 24mg/26mg, 49mg/51mg, and 97mg/103mg tablets 

What is the recommended dosage?

Generally, it is dosed 1 tablet by mouth twice daily but take as directed by your doctor. 

What is the maximum dosage?

The maximum recommended dosage is 194/206 mg/day.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is relatively close to when your next dose is due, wait until then and take a normal dose. Do not take an extra dose to make up for the missed dose. 


What should you know before you take Entresto (Sacubitril/Valsartan)?

Patients should monitor for signs and symptoms of angioedema (swelling of the tongue) as this is a potentially serious side effect of Entresto (Sacubitril/Valsartan).

Hypotension is a common side effect of Entresto (Sacubitril/Valsartan), talk with your doctor if you have significant dizziness with Entresto (Sacubitril/Valsartan). 

Patients with existing renal dysfunction or those at risk of developing it should be monitored regularly for renal injury.  

Side Effects

What are the side effects of Entresto (Sacubitril/Valsartan)?

Some common (≥5%) side effects include:

  • Hypotension
  • Hyperkalemia 
  • Cough 
  • Dizziness
  • Renal Failure 

Speak to your doctor for a full list of side effects.


Does this medication interact with other drugs, foods, or alcohol?

Patients with an eGFR <60 should avoid Entresto (Sacubitril/Valsartan) in combination with aliskiren. 

Potassium-sparing diuretics should be used with caution as they can increase a patient’s risk of developing hyperkalemia. 

Concomitant use of other agents known to cause kidney damage should be limited while on this medication. 

Patients taking lithium should be closely monitored while starting or changing dosages. 


How should this medication be stored?

Entresto (Sacubitril/Valsartan) should be stored at room temperature (68°F to 77°F). Protect Entresto (Sacubitril/Valsartan) from moisture. 

Pharmacist Tips

  • Patients transitioning from an ACEi therapy to Entresto (Sacubitril/Valsartan) should ensure that they have a 36 hour washout period before starting Entresto (Sacubitril/Valsartan). 
  • In order for Entresto (Sacubitril/Valsartan) to reach maximum effectiveness, it will need to be titrated to a maximum tolerated dosage. 
  • Talk with your doctor if you become or are trying to become pregnant. 


Can you take Entresto (Sacubitril/Valsartan) with milk?

Yes, the manufacturer has specified that food has no clinically significant effect on the absorption of Entresto (Sacubitril/Valsartan). 

What happens if you suddenly stop taking Entresto (Sacubitril/Valsartan)?

You should not discontinue Entresto (Sacubitril/Valsartan) unless otherwise instructed by your physician. Stopping Entresto (Sacubitril/Valsartan) can worsen your symptoms of heart failure if you stop taking it suddenly. 

Does Entresto (Sacubitril/Valsartan) strengthen your heart?

Entresto (Sacubitril/Valsartan) was shown to reduce death and hospitalization in patients with heart failure. The most benefit was found in patients with an ejection fraction below normal.

Does Entresto (Sacubitril/Valsartan) make you sleepy?

A frequent complaint of patients starting Entresto (Sacubitril/Valsartan) is dizziness, this dizziness is generally temporary when starting the medication or tolerating an increase in dose. 

Does Entresto (Sacubitril/Valsartan) lower heart rate?

No, Entresto (Sacubitril/Valsartan) functions to lower blood pressure by reducing the contraction of blood vessels in the body.