Effexor XR

Venlafaxine Hydrochloride

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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on August 18, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.


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How to buy Effexor XR (Venlafaxine ER) online?

Effexor XR can be ordered online through 90daymeds.com or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on 90daymeds.com.

Is a prescription required?

Yes, a valid prescription from your doctor is required. Effexor XR is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90-days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor.

Is it safe to order Venlafaxine ER online from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication.

Effexor XR Cost

Average US Retail Price 90-Day Meds Price
Effexor XR 150mg
$1986.56 (90 capsules) $95.00
(84 capsules)
Venlafaxine 150mg
(90 capsules)
(100 capsules)

How much does Effexor XR (Venlafaxine ER) cost?

Effexor XR is available as a brand and generic. Above shows the price comparison between the average U.S. retail price and 90-Day Meds for about a 90 day supply of brand and generic Effexor XR 150 mg capsules.

What is the lowest price of Effexor XR per unit?

Lowest Price Per Unit: $1.00/unit for Effexor 75mg at a quantity of 84 capsules.

Is this price for Effexor XR without insurance?

The above listed prices are without insurance. Unfortunately, we cannot accept insurance. However we will give you an official receipt in case it can qualify for a reimbursement from your insurer. We are also unable to adjudicate with U.S. insurance providers.

Why is Effexor cheaper from Canada than from the United States?

Prices of medications ordered from Canada are internally controlled by their respective governments. This differs from the US as it is a free market economy and pharmaceutical suppliers can charge what they deem a product is worth. As a result, we can offer lower prices to our patients as we source medications from these countries.

Effexor XR Coupon

Sorry, we do not have a Effexor XR (Venlafaxine Hydrochloride) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.


Is there a lower cost generic Effexor XR available?

Yes, Effexor is available as a lower cost generic, Venlafaxine XR.

How much cheaper is the generic Effexor XR?

Generic Effexor XR (Venlafaxine ER) is 40-60% cheaper than brand Effexor XR at a quantity of 100 capsules.

What is the difference between brand and generic Effexor XR?

The manufacturer of brand Effexor is Wyeth Inc. based out of Australia and the manufacturer of generic is Apotex Inc. out of Canada. Both are considered therapeutically equivalent. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. An email notification will be sent to you once the item has been shipped. There are no shipping charges.

Is express shipping available?

If a product of Canada is available then express shipping can be selected with an estimated delivery time of 3-5 business days. You have the option at the checkout page to select the express shipping option ($25) if available for that medication source.

How much does shipping cost?

Standard shipping is free.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Effexor XR?

Effexor XR is a prescription medication that is classified as a serotonin/norepinephrine reuptake inhibitor (SNRI) and antidepressant.


What is Effexor XR used for?

Effexor XR is a serotonin/norepinephrine reuptake inhibitor (SNRI) and antidepressant used for treatment of:

  • Generalized anxiety disorder (GAD)
    • Extended-release capsules only
  • Unipolar major depressive disorder (MDD)
  • Panic disorder
    • Extended-release capsules only
  • Social anxiety disorder
    • Extended-release capsules and tablets only

How does it work?

It exerts its antidepressant effects by inhibiting neuronal serotonin, norepinephrine and dopamine reuptake.


How to take Effexor XR?

Take your Effexor XR capsule whole by mouth with food. Do not chew or crush the capsule or its contents.

You may open up the capsule and sprinkle the pellets into a spoonful of applesauce to be swallowed immediately, not chewed. This should be followed by a glass of water to ensure all the pellets from the capsule are ingested.

What dosages are available?

Effexor XR is available as a capsule (generic only; 37.5mg, 75mg, 150mg, 225mg) or capsule (brand and generic; 37.5mg, 75mg, 150mg).

What is the recommended dosage?

The recommended starting dose for MDD, GAD, and PD is 37.5mg/day. The recommended starting dose for SAD is 75mg/day.

What is the maximum dosage?

The maximum dosage is 225mg/day.

What if I miss a dose?

Take the medication as soon as possible if you have missed a dose. If it is almost time for your next dose, skip the missed dose and return back to your regular schedule. Never double the doses.


What should you know before you take Effexor XR?

Serotonin syndrome risk can be increased if Effexor XR is taken concomitantly with triptans, tramadol, or other serotonergic agents.

Discontinuation syndrome: Do not abruptly stop taking your Effexor XR as symptoms may arise, commonly including vomiting, diarrhea, nausea, headache, lightheadedness, decreased appetite, dizziness, sleep disturbances, sweating, chills, fatigue, somnolence, tremors, paresthesias, and sweating.

Sexual dysfunction may occur or be exacerbated.

Caution in those with hepatic dysfunction. Dose reduction is recommended.

Caution in those with renal dysfunction. Dose reduction is recommended.

Caution in those with previous seizure disorders. Stop the medication in any patient that develops seizures.

Effexor XR may precipitate a shift to hypomania or mania in those with bipolar disorder.

Bone fractures have been associated with use of an antidepressant. In patients with unexplained bruising, swelling, bone pain, or point tenderness, it may be possible that it is a fragility fracture and the possibility should be considered.

Monitor blood pressure regularly as a dose-related increase in systolic and diastolic blood pressure have been reported. Dose reduction or discontinuation should be considered if sustained increases are seen.

Dose-dependent weight loss has been reported in both pediatric and adult patients and not limited to experiencing anorectic effects.

Effexor XR may cause a significant increase in total cholesterol and triglycerides. This should be monitored during long-term treatment.

Consider evaluating whether patients have not had an iridotomy for narrow-angle glaucoma risk factors due to a possibility of Effexor XR causing an acute episode of narrow-angle glaucoma.

Pediatric population: Effexor XR may cause insomnia, nervousness, and anxiety in the pediatric population. An increase in hyperactivity has been reported in children being treated for ADHD. Effexor XR may cause anorexia and significant, dose-related weight loss; caution should be used in those where weight loss is unwanted. Effexor XR may affect weight and height in children; close monitoring should be done.

U.S. Boxed Warning: Suicidal thoughts and behavior. Antidepressants increase the risk of suicidal thoughts/behavior in young adults and pediatric patients in short-term studies.

Side Effects

What are the side effects of Effexor XR?

Some common side effects include:

  • Nausea, vomiting
  • Somnolence
  • Dry mouth
  • Sweating
  • Anorexia, constipation, diarrhea
  • Impotence, decreased libido, abnormal ejaculation
  • Headache
  • Increased heart rate, anxiousness
  • Tremor

Speak to your doctor for a full list of side effects that apply to you if you are taking Effexor XR.


Does this medication interact with other drugs, foods, or alcohol?

Avoid use with bromopride, dapoxetine, iobenguane, linezolid, methylene blue, MAOi, rasagiline, safinamide, selegiline, and urokinase (Risk Category X).

This is not a full list of potential drug-drug-interactions. Speak to your doctor if you have any concerns about drug-drug-interactions.


How should this medication be stored?

Your Effexor ER capsules should be stored at room temperature between 20° to 25°C (68° to 77°F).

Pharmacist Tips

  • It will take a few weeks for you to start to see/feel the effects of your medication.
  • Notify your doctor immediately if you or a family are experiencing new or sudden changes in mood, behavior, feelings, or thoughts.
  • Do not stop taking your Effexor XR even if you start to feel better.
  • It is important that you continue to take your medication daily even if you feel like it is not working at first.


Is Effexor a SSRI?

No. Effexor is a SNRI.

What class of drug is Effexor XR?

Effexor XR is an antidepressant that is a SNRI.

Should I take my Effexor XR every day?

Yes. When starting your Effexor XR, it will take several weeks to see the effects of the medication. Abruptly stopping your medication can lead to “discontinuation syndrome”. Symptoms commonly include vomiting, diarrhea, nausea, headache, lightheadedness, decreased appetite, dizziness, sleep disturbances, sweating, chills, fatigue, somnolence, tremors, paresthesias, and sweating.

What are the most common side effects of Effexor XR?

Some common side effects of Effexor XR include nausea, vomiting, somnolence, dry mouth, sweating, anorexia, constipation, diarrhea, Impotence, decreased libido, abnormal ejaculation, headache, increased heart rate, anxiousness, and tremor.

What are the most serious side effects of Effexor XR?

Increased cholesterol levels, angle-closure glaucoma, and other serious side effects are listed in the “Precaution” section of the package insert.


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.