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Medically reviewed by: Samuel Maaiah, PharmD

Last updated on August 18, 2021

Dr. Maaiah is a PharmD graduate who has practiced both in pharmaceutical consulting and retail pharmacy. His interests include consulting and the development and approval of new therapeutics. He currently works as a Medical Information Consultant (MIC) and as a retail pharmacist. As a MIC he helps pharmaceutical companies with projects and by consulting as a medical information expert.

When Dr. Maaiah is not working, he enjoys spending time with his family and friends, doing outdoor activities, working out, and reading.


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How to buy Anafranil (Clomipramine Hydrochloride) online?

Anafranil can be ordered online through or by calling 1-800-828-4489 and speaking to customer support. The chat feature can also be used for support. For more information please visit the “How to Order” page on

Is a prescription required?

Yes, a valid prescription from your doctor is required. Anafranil is a prescription medication and can only be sold with a prescription. To process your order, you will need to submit a prescription. The prescription can be emailed ([email protected]), faxed (1-800-416-8019), or uploaded. Alternatively, we can reach out to your doctor to attain a valid prescription if you would like.

What is the maximum amount that can be ordered?

A 3-month supply (90 days) is the maximum amount that can be ordered at one time. Refills are kept on file for future orders. The amount that can be ordered will be based on the directions and quantity indicated on the prescription from your doctor.

Is it safe to order Anafranil (Clomipramine Hydrochloride) from 90-Day Meds?

Absolutely. All our partner pharmacies are fully licensed and certified in their respective countries. We ensure that your shopping experience is safe and secure with our Norton Shopping Guarantee. We operate just like your local pharmacy would, with our main priority being to provide you access to safe and affordable prescription medication


Average US Retail Price 90-Day Meds Price
Anafranil 50mg
(90 capsules)
(100 capsules)
Clomipramine HCl 50mg
(90 capsules)
(100 capsules)

How much does Anafranil (Clomipramine Hydrochloride) cost?

We provide both the brand and generic versions. 100 capsules of brand Anafranil costs $135.00, which comes out to $1.35/capsule. 100 capsules of generic Anafranil 50 mg  costs $45.00, which comes out to $0.45/capsule.

What is the lowest price of Anafranil per unit?

Lowest Price Per Unit: $0.59/unit for generic Anafranil (Clomipramine) 50mg capsules.

Is this price for Anafranil without insurance?

The listed prices above are not including insurance. Unfortunately, we are not able to process through insurance. However, we will give you an official receipt which you can use to apply for reimbursement with your insurer since we are also unable to adjudicate with US insurance providers.

Why is Anafranil cheaper from Canada than from the United States?

The cost of medications ordered from India, Canada, and Turkey are internally controlled by the respective governments. The US is a free market economy which is why the price differs since pharmaceutical suppliers can charge what they consider appropriate for the medication. As a result, we offer lower prices to our patients as we obtain medications from these countries.


Sorry, we do not have a Anafranil (Clomipramine) coupon at the moment, please check back later.

Yes, Check out the Coupon Section of this page.


Is there a lower cost generic Anafranil available?

Anafranil is available as a generic alternative.

How much cheaper is generic Anafranil?

Generic Anafranil (Clomipramine) is $90 cheaper than brand Anafranil at a quantity of 100 capsules. 

What is the difference between brand and generic Anafranil?

There is no difference between generic and brand Anafranil. Generic formulations of medications contain the same active ingredients and meet the same quality, strength, and purity standards as the brand formulation.


Is shipping available to the United States?

Yes. Your order will be shipped from Canada to the U.S. within 7 to 10 business days and within 10 to 18 business days from Mauritius or Turkey. An email notification will be sent to you once the item has been shipped. There are no shipping charges.

Is express shipping available?

Yes. You have the option at the checkout page to select the express shipping option ($25).

How much does shipping cost?

Standard shipping is free.

Refill RX

How to refill a prescription?

Refilling your prescription is made easy with 90-Day Meds. You can sign into your online account and view your previous orders and see which prescriptions we have on file. Placing a refill order online is made simple by accessing the reorder section in your account.

You can also call us and speak to customer support to place a refill. Our live chat is also a great place to connect with us to place a refill order while you are on the go.

Are prescriptions automatically refilled?

We do not automatically refill prescriptions as there can be cases where you are no longer taking the medication, your doctor has changed your dose, etc. However, we provide a friendly refill reminder service. We will kindly notify you by phone or email as to the best time to place a refill order based on your prescription history.

Drug Information


What is Clomipramine?

Anafranil is a tricyclic tertiary amine, antidepressant prescription medication.


What Anafranil used for?

Anafranil is indicated for the treatment of obsessive-compulsive disorder (OCD).


How to take Anafranil?

Initial dosing is 25 mg by mouth once daily, which can be increased as tolerated over the first two weeks, in divided doses (~100 mg/day). Your doctor will be titrating your medication. Do not increase or decrease your dose yourself.

Your maintenance dose of Anafranil will be determined by your doctor, after the initial titration.

You may divide your Anafranil dose and take with food to help decrease the risk of any gastrointestinal (GI) side effects

What dosages are available?

Anafranil comes in a capsule, as either brand or generic (25 mg, 50 mg, 75 mg).

What if I miss a dose?

Take your next dose of Anafranil as soon as possible. Skip the missed dose and return to your regular dosing schedule if it is almost time for your next dose. Never double doses.


What should you know before you take Clomipramine?

Anafranil falls under the Beers Criteria and is potentially an inappropriate medication.

Caution should be used in patients with BPH, xerostomia, urinary retention, visual problems, decreased GI motility, or paralytic ileus as Anafranil may cause anticholinergic effects (e.g., blurred vision, urinary retention, xerostomia, constipation).

Vomiting is 2- to 3-fold more common in children compared to adolescents and is more common in adolescents compared to adults. To help decrease the risk of vomiting, Anafranil doses can be divided and taken with food initially.

U.S. Boxed Warning:  Antidepressants can increase suicidal thinking/behavior in those 18 to 24 years of age with major depressive disorder (MDD) and other psychiatric disorders.

Side Effects

What are the side effects of Anafranil?

The most common side effects of Anafranil include:

  • Dizziness, drowsiness, headache, insomnia, nervousness, myoclonus
  • Diaphoresis
  • Change in libido, weight gain
  • Xerostomia, constipation, nausea, dyspepsia, anorexia, diarrhea, abdominal pain, increased appetite
  • Ejaculation failure, impotence, difficulty in micturition
  • Tremor, myalgia
  • Visual disturbance
  • PharyngitisSpeak to your doctor for a full list of side effects that apply to you if you are taking Anafranil.


Are there any interaction concerns?

Abametapir may increase the serum concentration of CYP1A2 substrates, which Anafranil is. Combination use should be avoided (Risk Category X).

Aclidinium may increase the anticholinergic effects of Anafranil and combination use should be avoided (Risk Category X).

Anafranil may increase the vasopressor effect of alpha- and beta- agonists, and combination use should be avoided if possible (Risk Category D).

Anafranil may decrease the antihypertensive effect of alpha2-agonists and combination use should be avoided if possible (Risk Category D).

This is not a full list of potential drug-drug-interactions. Please speak to your doctor for a list of potential drug-drug-interactions.


How should this medication be stored?

Anafranil should be stored at 20° to 25°C (68° to 77°F) and kept away from moisture.

Pharmacist Tips

  • During a dose increase, you may divide your dose and take your Anafranil to decrease the risk of any GI side effects. Capsules can be opened to divide the dose, but do not chew the capsules.
  • Never stop taking your antidepressant without first speaking to your doctor.
  • Do not take an MAO inhibitor within 2 weeks of stopping your Anafranil unless directed to do so by your doctor.
  • Call your doctor right away if you or your family is experiencing any of the following symptoms, especially if they are new, worsening, or are worrisome:
    • Thoughts about dying/suicide
    • Suicide attempts
    • New or worse depression, anxiety, or irritability
    • Feeling restless or agitated
    • Insomnia
    • Panic attacks
    • Acting violent, angry, or aggressive
    • Mania
    • Any other unusual changes in mood or behavior


Does Anafranil cause weight gain?

Yes. Anafranil can cause weight gain. Weight gain occurs in about 18% in adults and 2% in children/adolescents.

Does Anafranil cause constipation?

Yes. Anafranil can cause constipation. Constipation occurs in about 47% of adults and 22% of children/adolescents.

Does Anafranil cause nausea?

Yes. Anafranil can cause nausea. Nausea occurs in about 33% of adults.

Does Anafranil make you sleepy?

Yes, in a way. Anafranil can make you feel drowsy and fatigued and can also cause insomnia, which can worsen or make you feel more fatigued. Drowsiness occurs in about 46-54% of adults, fatigue occurs in about 35-39% of adults, and insomnia occurs in about 25% and 11% of children and adolescents.

What are the side effects of Anafranil?

There are many potential side effects of Anafranil. You can get a full list of potential side effects of Anafranil by speaking to your doctor. The most common side effects of Anafranil include dizziness, drowsiness, headache, insomnia, xerostomia, constipation, tremor, nausea, and ejaculation failure


This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs before taking any medication.